Technical Assistant / Lab Manager (m/f/d) in the area of Leukemia and Chromatin Biology

The St. Anna Children’s Cancer Research Institute (CCRI)

Job Overview

St. Anna Kinderkrebsforschung CCRI - Children`s Cancer Researche Institute

Technical Assistant / Lab Manager (m/f/d) in the area of Leukemia and Chromatin Biology

Location:
Vienna

Research group:
Davide Seruggia Group

Working hours:
Full-time

We are recruiting a Technical Assistant / Lab Manager (m/f/d) to join our newly formed research group focused on chromatin biology and pediatric leukemia. Our lab is based at the Children’s Cancer Research Institute (CCRI) of the St. Anna Kinderkrebsforschung Association in Vienna (Austria). The Institute is located in the heart of beautiful Vienna, a European metropolis full of history, music and fine arts. CCRI is a renowned research institution with tight links to the St. Anna Children’s Hospital, a leading pediatric cancer center in Europe and well connected through various European and international networks. The ultimate aim of our research at CCRI is to improve treatment outcome of malignant diseases in children and adolescents by performing basic, translational and clinical research. Additional information on the CCRI can be found at http://science.ccri.at/.

Our group (www.seruggialab.com) is interested in gene regulation in the context of pediatric cancer, and focuses on the study of non-coding regulatory sequences (enhancers) as well as protein complexes involved in the control of gene expression. We use genome editing (CRISPR screenings, CRISPRi/a, dense mutagenesis), chromatin profiling (ChIP-seq, CUT and RUN, ATAC-seq), proteomics, mouse models and computational approaches to identify and characterize cancer vulnerabilities. The project is funded by a Starting Grant from the ERC and will investigate how mutations at enhancers drive leukemia development and will elucidate the effect of sequence variation at transcription factor binding sites. We are also interested in cracking the 3D genome organization in healthy and malignant hematopoiesis. Our group is also affiliated with the CeMM, where we have access to top-notch facilities for next-generation sequencing, proteomics and metabolomics.

Relevant publications: Seruggia et al. Molecular Cell 2019; Sher, Hossain, Seruggia et al. Nature Genetics 2019; Seruggia et al. Scientific Reports 2020; Debruyne et al. Nature 2019; Seruggia et al Nucleic Acids Research 2015.

Your responsibilities

  • Contribute wet-lab work and expertise to collaborative research projects
  • Optimization and testing of new protocols
  • Actively participate in group meetings and scientific discussions
  • Lab management, ordering, maintenance of lab inventories and minor administrative tasks
  • Training of new lab members in established and new protocols

Your profile

  • Bachelor or Master degree in life sciences with strong wet-lab experience
  • High accuracy, reliability, precision, and strong organizational skills
  • High motivation and commitment, proactive and energetic mindset, getting-things-done attitude
  • Friendly, collaborative mindset and ability to work well in an international environment
  • Excellent tissue culture skills working with cancer cell lines and primary human cells
  • Experience with DNA/RNA assays including library preparation for next generation sequencing is a plus
  • Experience with mouse models is a plus
  • Written and oral communication skills in English (German not required)

Our offer

  • A meaningful, inspiring, and international environment
  • An outstanding working atmosphere in a strong team with excellent research and development opportunities
  • Access to state-of-the-art infrastructure
  • Flexible working hours, discounted lunch in our canteen and other great benefits
  • Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
  • A fair and attractive salary package starting at € 2.500,– gross (14x per year) on full-time basis with a view to increase based on your qualification and experience

Who we are

The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).

The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.

Find more information here: https://science.ccri.at/

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