Master Thesis in the field of Tumor Immunoediting
To strengthen our excellent research team, which is focused on the development and research of innovative approaches for the treatment of childhood cancer, we are looking for a Master student (m/f/d). In this responsible role, you will have the unique opportunity to be part of a multidisciplinary competence center for pediatric oncology and to have a direct influence on the development of new cancer therapies.
The group of Eva Maria König studies the role of natural killer (NK) cells in tumor immunoediting and aims to find novel therapeutic targets to increase the susceptibility of tumor cells towards NK cell-mediated surveillance and/or to enhance NK cell functionality per se (https://science.ccri.at/research/research-areas/immunology/tumour-immunoediting/). In recent years, novel anti-cancer therapies have reached clinics and shown promising results. However, we are still facing challenges caused by resistance to therapy and secondary metastasis. Our group mainly investigates the applicability of NK cells as anti-cancer regimen and we constantly aim to find novel ways to enhance their functionality. Our previous studies focusing on intracellular signaling molecules in NK cells revealed the unique opportunity to increase NK cell functionality by modulating the JAK/STAT pathway (e.g. Putz et al Cell Reports 2013, OncoImmunology 2016 and 2017). The core of the current project is to further elucidate non-canonical STAT1 signaling in NK cells with the ultimate goal to find novel therapeutic targets to increase the cytotoxic function of NK cells against tumor cells.
As a Master student, you will
- Work in close collaboration with other team members in designing, initiating, and executing research project/s
- Learn and work primarily with cutting-edge technologies (amongst others, you will work with primary human NK cells and tumor cell lines and apply diverse immunological and molecular biology techniques, such as modification of gene expression by siRNA knockdown, multicolor flow cytometry including the staining of intracellular proteins, functional in vitro assays, western blotting and immune fluorescence)
- Present your work progress internally and/or externally
- Bachelor in Biology or other related fields
- First work experience (in the form of internships) in working with cancer research, immunology, or related fields
- Hands-on experience with basic molecular biology techniques is required
- Excellent verbal and written communication skills in English (German not required)
- Proactive personality and high level of enthusiasm as well as determination and creativity
- Willingness to learn
- Master thesis in the group of Tumor Immunoediting, under the supervision of Eva Maria König
- A 12 months contract for a Master student position in a meaningful, inspiring, and international environment
- An outstanding working atmosphere in a strong team with excellent research and development opportunities
- Access to state-of-the-art infrastructure
- Flexible working hours, discounted lunch in our canteen and other great benefits
- Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
- A monthly allowance of € 460,66
Who we are
The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).
The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.